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. 2015 Apr;41(4):481-6.
doi: 10.1097/DSS.0000000000000292.

Family history of skin cancer is associated with increased risk of cutaneous squamous cell carcinoma

Maryam M Asgari  1 , E Margaret Warton, Alice S Whittemore
Affiliations

Family history of skin cancer is associated with increased risk of cutaneous squamous cell carcinoma

Maryam M Asgari et al. Dermatol Surg. 2015 Apr.

Abstract

Background: The contribution of family history to cutaneous squamous cell carcinoma (SCC) risk has not been systematically quantified.

Objective: To examine the association between self-reported family history of skin cancer and SCC risk.

Methods and materials: Cases (n = 415) with a pathology-verified SCC and 415 age-, gender-, and race-matched controls were identified within a large integrated health care delivery system. Family history and skin cancer risk factors were ascertained by survey. Odds ratios (ORs) for associations of SCC with family history of skin cancer were estimated using conditional logistic regression adjusted for environmental and innate SCC risk factors.

Results: Any known family history of skin cancer was associated with a four-fold higher risk of SCC, adjusting for known environmental and innate SCC risk factors (OR, 4.0; confidence interval [CI]: 2.5-6.5). An unknown family history of skin cancer showed similar risk for SCC (OR, 3.9; CI: 2.4-6.5). In models including skin cancer type, the strongest association was for family history of basal cell carcinoma (OR, 9.8; CI: 2.6-36.8) and for multiple skin cancer types (OR, 10.5; CI: 3.7-29.6).

Conclusion: Family history of skin cancer is an important independent risk factor for cutaneous SCCs.

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Conflict of interest statement

The authors have indicated no significant interest with commercial supporters.

Figures

Figure 1
Figure 1
Adjusted models for the association of SCC risk with family history of skin cancer.
Figure 2
Figure 2
Adjusted models for the association of SCC risk with family history of skin cancer by skin cancer type.
See this image and copyright information in PMC

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