Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Mar 12:21:29-32.
doi: 10.12659/MSMBR.894020.

Utilization of the organ care system - a game-changer in combating donor organ shortage

Aron-Frederik Popov  1 , Diana García Sáez  1 , Anton Sabashnikov  1 , Nikhil P Patil  1 , Mohamed Zeriouh  1 , Prashant N Mohite  1 , Bartlomiej Zych  1 , Bastian Schmack  2 , Arjang Ruhparwar  2 , Klaus Kallenbach  2 , Pascal M Dohmen  3 , Matthias Karck  2 , Andre R Simon  1 , Alexander Weymann  1
Affiliations
Review

Utilization of the organ care system - a game-changer in combating donor organ shortage

Aron-Frederik Popov et al. Med Sci Monit Basic Res. .

Abstract

For patients with end-stage heart failure, cardiac transplantation persists to be the gold standard. Nevertheless, the availability of organs remains a main constraint to the treatment. Through mounting usage of ex vivo heart perfusion an increase in organ availability was achieved by reconditioning of organs formerly not regarded as appropriate for transplantation. We propose the future standard application of this state-of-the-art technology to improve the pool of donor organs by evaluating hearts outside standard acceptability criteria.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic illustration of OCS paradigm in donor organ pool expansion. The system permits direct cannulation of the graft to the system at the donor site with uninterrupted warm perfusion of a resuscitated organ until implantation, thus reducing the harmful effects of cold storage, ischemia/reperfusion injury and affording continued assessment of graft viability after donor death with enhancement of “marginal” donor allografts. DBD, donation after brain death; cDCD, controlled donation after cardiac death; uDCD, uncontrolled donation after cardiac death; OCS, Organ Care System
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. García Sáez D, Zych B, Sabashnikov A, et al. Evaluation of the organ care system in heart transplantation with an adverse donor/recipient profile. Ann Thorac Surg. 2014;98:2099–105. discussion 2105–6. - PubMed
    1. García Sáez D, Elbetanony A, Lezberg P, et al. Ex vivo heart perfusion after cardiocirculatory death; a porcine model. J Surg Res. 2014 pii: S0022-4804(14)01157-3 [Epubahead of print] - PubMed
    1. Boucek M, Mashburn C, Dunn SM, et al. Pediatric heart transplantation after declaration of cardiocirculatory death. N Engl J Med. 2008;359:709–14. - PubMed
    1. Veatch RM. Donating hearts after cardiac death – reversing the irreversible. N Engl J Med. 2008;359:672–73. - PubMed
    1. Daemen JW, Kootstra G, Wijnen RM, et al. Nonheart-beating donors: The Maastricht experience. Clin Transplant. 1994:303–16. - PubMed