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Review
. 2015 Mar 12:21:29-32.
doi: 10.12659/MSMBR.894020.

Utilization of the organ care system - a game-changer in combating donor organ shortage

Aron-Frederik Popov  1 , Diana García Sáez  1 , Anton Sabashnikov  1 , Nikhil P Patil  1 , Mohamed Zeriouh  1 , Prashant N Mohite  1 , Bartlomiej Zych  1 , Bastian Schmack  2 , Arjang Ruhparwar  2 , Klaus Kallenbach  2 , Pascal M Dohmen  3 , Matthias Karck  2 , Andre R Simon  1 , Alexander Weymann  1
Affiliations
Review

Utilization of the organ care system - a game-changer in combating donor organ shortage

Aron-Frederik Popov et al. Med Sci Monit Basic Res. .

Abstract

For patients with end-stage heart failure, cardiac transplantation persists to be the gold standard. Nevertheless, the availability of organs remains a main constraint to the treatment. Through mounting usage of ex vivo heart perfusion an increase in organ availability was achieved by reconditioning of organs formerly not regarded as appropriate for transplantation. We propose the future standard application of this state-of-the-art technology to improve the pool of donor organs by evaluating hearts outside standard acceptability criteria.

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Figures

Figure 1
Figure 1
Schematic illustration of OCS paradigm in donor organ pool expansion. The system permits direct cannulation of the graft to the system at the donor site with uninterrupted warm perfusion of a resuscitated organ until implantation, thus reducing the harmful effects of cold storage, ischemia/reperfusion injury and affording continued assessment of graft viability after donor death with enhancement of “marginal” donor allografts. DBD, donation after brain death; cDCD, controlled donation after cardiac death; uDCD, uncontrolled donation after cardiac death; OCS, Organ Care System
See this image and copyright information in PMC

References

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