Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Apr;32(4):112.
doi: 10.1007/s12032-015-0524-z. Epub 2015 Mar 12.

Serine protease HtrA1 as an inhibitor on proliferation invasion and migration of gastric cancer

Zhiguo Zhao  1 , Huifang Li, Chuanyi Wang, Wanfang Xu, Junfeng Sun, Wenzhao Zhao
Affiliations

Serine protease HtrA1 as an inhibitor on proliferation invasion and migration of gastric cancer

Zhiguo Zhao et al. Med Oncol. 2015 Apr.

Abstract

HtrA1, as serine protease lower expressed in various human solid tumors, can down-regulate cell growth and proliferation. In this study, we focus on whether overexpressed HtrA1 can inhibit the growth of gastric cancer in vitro. This study found the HtrA1 is lower expressed in gastric cancer tissue than in normal gastric tissue. When HtrA1 is highly expressing with recombinant plasmid in gastric cancer cell lines SGC-7901 and AGS, it weakened cell proliferation, invasion, and migration in vitro. These data suggested that HtrA1 as an inhibitor in gastric cancer cells resulted in anti-proliferation, reduced invasion, decreased migration, and suppressed growth and may be an effective molecular targets on gastric cancer treatment.

PubMed Disclaimer

References

    1. Mol Pharmacol. 2011 Jan;79(1):106-18 - PubMed
    1. Cancer Cell. 2005 Nov;8(5):393-406 - PubMed
    1. J Cancer Res Clin Oncol. 2009 May;135(5):723-30 - PubMed
    1. J Clin Invest. 2006 Jul;116(7):1994-2004 - PubMed
    1. Anticancer Res. 2006 Sep-Oct;26(5A):3455-9 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources