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Editorial
. 2015 Jul;62(1):19-21.
doi: 10.1002/hep.27780. Epub 2015 Apr 8.

The Na(+) -taurocholate cotransporting polypeptide knockout mouse: A new tool for study of bile acids and hepatitis B virus biology

Astrid Kosters  1 , Paul A Dawson  1
Affiliations
Editorial

The Na(+) -taurocholate cotransporting polypeptide knockout mouse: A new tool for study of bile acids and hepatitis B virus biology

Astrid Kosters et al. Hepatology. 2015 Jul.
No abstract available

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Figures

Fig 1
Fig 1
Working model of the phenotype of the human and mouse NTCP/Ntcp deficiency. BA, unconjugated bile acid; BSEP, bile salt export pump; OATP, organic anion transporting polypeptide; T/G-BA, taurine/glycine-conjugated bile acid.
See this image and copyright information in PMC

Comment on

References

    1. Hagenbuch B, Stieger B, Foguet M, Lubbert H, Meier PJ. Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A. 1991;88:10629–10633. - PMC - PubMed
    1. Vaz FM, Paulusma CC, Huidekoper H, de Ru M, Lim C, Koster J, Ho-Mok K, et al. Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype. Hepatology. 2015;61:260–267. - PubMed
    1. Slijepcevic D, Kaufman C, Wichers C, Gilglioni E, Lempp F, Duijst S, de Waart D, Oude Elferink RPJ, Mier W, Stieger B, Beuers U, Urban S, van de Graaf S. Impaired uptake of conjugated bile acids and Hepatitis B Virus preS1-binding in Na+-taurocholate cotransporting polypeptide knockout mice. Hepatology. 2015;61 - PMC - PubMed
    1. Ho RH, Tirona RG, Leake BF, Glaeser H, Lee W, Lemke CJ, Wang Y, et al. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology. 2006;130:1793–1806. - PubMed
    1. Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, Huang Y, et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife. 2012;1:e00049. - PMC - PubMed

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