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Comment
. 2015 Mar 24;112(12):3589-90.
doi: 10.1073/pnas.1502590112. Epub 2015 Mar 11.

Emerging picture of the distinct traits and functions of microvesicles and exosomes

Marc A Antonyak  1 , Richard A Cerione  2
Affiliations
Comment

Emerging picture of the distinct traits and functions of microvesicles and exosomes

Marc A Antonyak et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
(A) Exosomes and MVs are two forms of EVs generated through distinct mechanisms. Exosomes form as a result of multivesicular bodies (MVBs) containing endosomes being trafficked from the cytosol to the cell surface. The MVBs then fuse with the plasma membrane, releasing exosomes into the extracellular space. In contrast, MV biogenesis occurs through the outward budding and fission of the plasma membrane. (B) Cancer cells use EVs to communicate with other cells in its environment to drive tumor progression. The transfer of EVs between cancer cells promotes their growth and survival. However, EVs also can stimulate endothelial cells to form blood vessels, as well as promote the growth, survival, and migration of tumor-associated fibroblasts.
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