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Comment
. 2015 Apr 15;34(8):978-80.
doi: 10.15252/embj.201591392. Epub 2015 Mar 11.

Unsaturated fatty acid-induced non-canonical autophagy: unusual? Or unappreciated?

Vytas A Bankaitis  1
Affiliations
Comment

Unsaturated fatty acid-induced non-canonical autophagy: unusual? Or unappreciated?

Vytas A Bankaitis. EMBO J. .

Abstract

The breakdown of cellular components via autophagy is crucial for cellular homeostasis.In this issue of The EMBO Journal,Niso-Santano et al (2015) report the important observation that feeding cells with saturated or unsaturated fatty acids triggers mechanistically distinct autophagic responses. Feeding cells saturated fatty acid induced the canonical, BECN1/PI3K dependent autophagy pathway. Conversely,the unsaturated fatty acid oleate triggered autophagic responses that were independent of the BECN1/PI3K complex, but that required a functional Golgi system.

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Figures

Figure 1
Figure 1
Canonical and non-canonical autophagy pathways Canonical autophagic pathway (A) involves different components than the LC3-associated phagocytosis pathway (B) and the oleate-induced non-canonical autophagic pathway (C).
See this image and copyright information in PMC

Comment on

  • Unsaturated fatty acids induce non-canonical autophagy.
    Niso-Santano M, Malik SA, Pietrocola F, Bravo-San Pedro JM, Mariño G, Cianfanelli V, Ben-Younès A, Troncoso R, Markaki M, Sica V, Izzo V, Chaba K, Bauvy C, Dupont N, Kepp O, Rockenfeller P, Wolinski H, Madeo F, Lavandero S, Codogno P, Harper F, Pierron G, Tavernarakis N, Cecconi F, Maiuri MC, Galluzzi L, Kroemer G. Niso-Santano M, et al. EMBO J. 2015 Apr 15;34(8):1025-41. doi: 10.15252/embj.201489363. Epub 2015 Jan 13. EMBO J. 2015. PMID: 25586377 Free PMC article.

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