doi: 10.1021/acs.orglett.5b00345.
Epub 2015 Mar 12.
Total synthesis and structural revision of mycalol, an anticancer natural product from the marine source
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- PMID: 25763453
- DOI: 10.1021/acs.orglett.5b00345
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Total synthesis and structural revision of mycalol, an anticancer natural product from the marine source
Org Lett.
.
Abstract
The total synthesis of an anticancer (anaplastic thyroid) natural lipid mycalol has been accomplished for the first time. Synthesis of originally proposed structure necessitated the revision of structure in which the position of acetate group moved from C20 to C19 and a change in stereochemistry of the glycerol unit.
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