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. 2016 Dec;23(6):829-834.
doi: 10.1111/1744-7917.12218. Epub 2015 Jun 3.

First report of L1014F kdr mutation in Culex quinquefasciatus in Mexico

Gustavo Ponce  1 , Iram P Sanchez  1 , Selene M García  1 , Jose M Torrado  1 , Saúl Lozano-Fuentes  2 , Beatriz Lopez-Monroy  1 , Adriana E Flores  1
Affiliations

First report of L1014F kdr mutation in Culex quinquefasciatus in Mexico

Gustavo Ponce et al. Insect Sci. 2016 Dec.

Abstract

The L1014F mutation in the voltage-sodium channel gene has been associated with resistance to DDT and pyrethroids in various arthropod species including mosquitoes. We determined the frequency of the L1014F kdr mutation in 16 field populations of Culex quinquefasciatus from Northeastern Mexico collected between 2008 and 2013. The L1014F was present in all populations analyzed with the lowest frequency (3.33%) corresponding to the population from Monclova collected in 2012, and the highest frequency (63.63%) from the Monterrey population collected in 2012. The presence of a kdr mutation in populations of Cx. quinquefasciatus from northeastern Mexico provides evidence of pyrethroid resistance. This requires a special attention, considering that pyrethroid-based insecticides are commonly used in vector-control campaigns, especially against Aedes aegypti (L.).

Keywords: Culex quinquefasciatus; L1014F mutation; insecticide resistance; kdr.

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