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Published Erratum
. 2015 Mar 12;34(6):828.
doi: 10.15252/embj.201570610.

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres

Sophie Badie, Ana Rita Carlos, Cecilia Folio, Keiji Okamoto, Peter Bouwman, Jos Jonkers, Madalena Tarsounas
Published Erratum

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres

Sophie Badie et al. EMBO J. .
No abstract available

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Figures

Figure 7
Figure 7
Model for the role of BRCA1-CtIP in A-NHEJ Telomeres uncapped by TRF2 depletion undergo 3′ overhang excision in MRN-dependent manner. Most telomeres are bound by Ku heterodimer and re-joined by C-NHEJ promoted by 53BP1. A subset of the telomeres become substrates for resection reactions, which require MRN, BRCA1 and CtIP. Initiation of resection generates short 3′ telomeric overhangs, whose annealing is facilitated by the homology provided by 2 A-T base pairs per telomeric repeat. The resulting flaps are cleaved by EXO1 and telomeres re-joined through the LIG3-dependent A-NHEJ pathway.
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