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. 2015 Aug;181(2):338-42.
doi: 10.1111/cei.12627.

Chemokine CXCL-1: activity in the vitreous during proliferative vitreoretinopathy

C Symeonidis  1 , S Androudi  2 , I Georgalas  3 , A Tzamalis  1 , N Chalvatzis  1 , T Rotsos  3 , E Souliou  4 , E Diza  5 , S A Dimitrakos  1
Affiliations

Chemokine CXCL-1: activity in the vitreous during proliferative vitreoretinopathy

C Symeonidis et al. Clin Exp Immunol. 2015 Aug.

Abstract

The aim of this study was to investigate CXCL-1 chemokine levels in the vitreous during rhegmatogenous retinal detachment (RRD) with and without proliferative vitreoretinopathy (PVR) and identify possible correlations with clinical parameters (extent and duration or RRD and PVR grade). Vitreous samples from patients with primary RRD with or without PVR were collected and assayed using a double antibody enzyme-linked immunosorbent assay (ELISA). Eleven vitreous samples from organ donors were employed as a control group. CXCL-1 levels were measured in 35 vitreous samples from 35 RRD patients. Mean CXCL-1 levels (64·82 ± 6·47 pg/ml) were significantly higher (P = 0·048) compared to controls. There was a significant positive correlation between CXCL-1 levels and the extent of the detachment (r = 0·794, P = 0·006). Peak CXCL-1 levels coincided with 3+ quadrant RRD, an interim of 29-60 days' duration and PVR grade B. Increased CXCL-1 levels may be indicative of mild inflammation in the detached retina and the adjacent vitreous. The results of the present study may provide novel insight into the complex interactions taking place during the early and late stages of RRD complicated by PVR.

Keywords: CXCL-1; GRO-α; proliferative vitreoretinopathy; rhegmatogenous retinal detachment; subretinal fluid.

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Figures

Figure 1
Figure 1
Graphical representation of mean CXCL-1 levels as per extent and duration of the detachment and proliferative vitreoretinopathy in the vitreous of patients with rhegmatogenous retinal detachment.
See this image and copyright information in PMC

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