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Case Reports
. 2015 Feb;3(2):121-5.
doi: 10.1002/ccr3.170. Epub 2014 Nov 17.

Toxic epidermal necrolysis and hemophagocytic lymphohistiocytosis: a case report and literature review

Jonathan D S Sniderman  1 , Geoff D E Cuvelier  2 , Stasa Veroukis  3 , Gregory Hansen  3
Affiliations
Case Reports

Toxic epidermal necrolysis and hemophagocytic lymphohistiocytosis: a case report and literature review

Jonathan D S Sniderman et al. Clin Case Rep. 2015 Feb.

Abstract

Diagnostic criteria for hemophagocytic lymphohistiocytosis should be reviewed early in critically ill patients with toxic epidermal necrolysis, multisystem dysfunction, and a deteriorating clinical trajectory.

Keywords: Critical illness; hemophagocytic lymphohistiocytosis; toxic epidermal necrolysis.

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Figures

Figure 1
Figure 1
(A) Evolving maculopapular rash prior to desquamation; (B) Upper chest skin biopsy showing completely detached epidermis and full epidermal necrosis; (C) Bone marrow aspirate demonstrating monocytes engulfing red blood cell precursors. (Giemsa stain).
See this image and copyright information in PMC

References

    1. Schwartz RA, McDonough PH. Lee BW. Toxic epidermal necrolysis. Part I. Introduction, history, classification, clinical features, systemic manifestations, etiology, and immunopathogenesis. J. Am. Acad. Dermatol. 2013;69:173.e1–173.e13. - PubMed
    1. Ferrandiz-Pulido C. Garcia-Patos V. A review of causes of Stevens-Johnson syndrome and toxic epidermal necrolysis in children. Arch. Dis. Child. 2013;98:998–1003. - PubMed
    1. Mehta RS. Smith RE. Hemophagocytic lymphohistiocytosis (HLH): a review of literature. Med. Oncol. 2013;30:740. - PubMed
    1. Henter J, Elinder G, Soder O. Ost A. Incidence in Sweden and clinical features of familial hemophagocytic lymphohistiocytosis. Acta Paediatr. Scand. 1991;80:428–435. - PubMed
    1. Ariffin H, Lum SH, Cheok SA, Shekhar K, Ariffin WA, Chan LL, et al. Haemophagocytic lymphohistiocytosis in Malaysian children. J. Paediatr. Child Health. 2005;41:136–139. - PubMed

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