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Comment
. 2015 Apr 7;112(14):E1694.
doi: 10.1073/pnas.1501817112. Epub 2015 Mar 13.

Reply to Liu et al.: Loss of TGF-β signaling in CARASIL pathogenesis

Nathalie Beaufort  1 , Eva Scharrer  1 , Vanda Lux  2 , Michael Ehrmann  2 , Christof Haffner  3 , Martin Dichgans  4
Affiliations
Comment

Reply to Liu et al.: Loss of TGF-β signaling in CARASIL pathogenesis

Nathalie Beaufort et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Comment on

References

    1. Liu J, Dong F, Hoh J. Loss of HtrA1-induced attenuation of TGF-β signaling in fibroblasts might not be the main mechanism of CARASIL pathogenesis. Proc Natl Acad Sci USA. 2015;112:E1693. - PMC - PubMed
    1. Beaufort N, et al. Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling. Proc Natl Acad Sci USA. 2014;111(46):16496–16501. - PMC - PubMed
    1. Doyle AJ, et al. Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm. Nat Genet. 2012;44(11):1249–1254. - PMC - PubMed
    1. Dietz H. A healthy tension in translational research. J Clin Invest. 2014;124(4):1425–1429. - PMC - PubMed

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