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. 2015 Mar 15:280:66-8.
doi: 10.1016/j.jneuroim.2015.03.003. Epub 2015 Mar 5.

Epitopes of HERV-Wenv induce antigen-specific humoral immunity in multiple sclerosis patients

Giuseppe Mameli  1 , Davide Cossu  2 , Eleonora Cocco  3 , Jessica Frau  3 , Maria Giovanna Marrosu  3 , Magdalena Niegowska  2 , Leonardo Antonio Sechi  4
Affiliations

Epitopes of HERV-Wenv induce antigen-specific humoral immunity in multiple sclerosis patients

Giuseppe Mameli et al. J Neuroimmunol. .

Abstract

To verify the serological response mounted against antigenic peptides from HERV-Wenv protein, we analyzed 80 multiple sclerosis (MS) serum samples, 27 of which were re-analyzed after a 6-month follow-up IFN-β therapy, and 73 healthy controls. Indirect ELISAs were carried out to detect antibodies specific for all the synthetic peptides derived from HERV-Wenv. Two antigenic peptides, HERV-Wenv93-108 (31.25%, p<0.0001) and HERV-Wenv248-262 (15%, p=0.02), were highly recognized by MS patients' antibodies when compared to healthy subjects. Moreover, antibody titer against these two peptides slightly decreased after six months of IFN-β-based therapy.

Keywords: HERV-Wenv; Humoral response; IFN-β therapy.

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