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. 2015 Aug;68(2):173-4.
doi: 10.1016/j.eururo.2015.02.041. Epub 2015 Mar 12.

"Sterile Urine" and the Presence of Bacteria

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"Sterile Urine" and the Presence of Bacteria

Alan J Wolfe et al. Eur Urol. 2015 Aug.

Abstract

Adult human urine is not sterile. The resident bacterial community may contribute to urinary health and disease in undiscovered ways. Bacterial genomic sequencing and expanded urine culture techniques are major complementary tools for scientific exploration in urologic research.

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References

    1. Brubaker L, Nager CW, Richter HE, Visco A, Nygaard I, Barber MD, Schaffer J, Meikle S, Wallace D, Shibata N, et al. Urinary bacteria in adult women with urgency urinary incontinence. Int Urogynecol J. 2014;25:1179–84. - PMC - PubMed
    1. Fouts DE, Pieper R, Szpakowski S, Pohl H, Knoblach S, Suh MJ, Huang ST, Ljungberg I, Sprague BM, Lucas SK, et al. Integrated next-generation sequencing of 16S rDNA and metaproteomics differentiate the healthy urine microbiome from asymptomatic bacteriuria in neuropathic bladder associated with spinal cord injury. J Transl Med. 2012;10:174. - PMC - PubMed
    1. Hilt EE, McKinley K, Pearce MM, Rosenfeld AB, Zilliox MJ, Mueller ER, Brubaker L, Gai X, Wolfe AJ, Schreckenberger PC. Urine is not sterile: use of enhanced urine culture techniques to detect resident bacterial flora in the adult female bladder. J Clin Microbiol. 2014;52:871–876. - PMC - PubMed
    1. Kass EH. Pyelonephritis and bacteriuria. A major problem in preventive medicine. Ann Intern Med. 1962;56:46–53. - PubMed
    1. Khasriya R, Sathiananthamoorthy S, Ismail S, Kelsey M, Wilson M, Rohn JL, Malone-Lee J. Spectrum of bacterial colonization associated with urothelial cells from patients with chronic lower urinary tract symptoms. J Clin Microbiol. 2013;51:2054–2062. - PMC - PubMed

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