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. 2014 Oct-Dec;15(4):99-105.
doi: 10.4103/1995-705X.151081.

The SYNTAX Score Can Predict Major Adverse Cardiac Events Following Percutaneous Coronary Intervention

Hadi Safarian  1 , Mohammad Alidoosti  2 , Akbar Shafiee  1 , Mojtaba Salarifar  1 , Hamidreza Poorhosseini  1 , Ebrahim Nematipour  1
Affiliations

The SYNTAX Score Can Predict Major Adverse Cardiac Events Following Percutaneous Coronary Intervention

Hadi Safarian et al. Heart Views. 2014 Oct-Dec.

Abstract

Objectives: The SYNTAX score is a grading system that evaluates the complexity and prognosis of patients undergoing percutaneous coronary intervention (PCI). We investigated the association between the incidence of major adverse cardiac events (MACE) following PCI and the SYNTAX score in patients with three-vessel disease.

Methods: We consecutively enrolled 381 patients with three-vessel disease undergoing PCI and stenting. The SYNTAX score was divided into tertiles as low (≤16), intermediate (16-22) and high (>22). The endpoint was the incidence of MACE defined as cardiac death, in-hospital mortality, nonfatal myocardial infarction (MI), or target vessel revascularization. Then, the incidence of MACE was compared among the SYNTAX score tertile groups.

Results: The median follow-up was 14 months, and the rate of MACE was 12.6%. The rates of MACE were 7.5%, 9.9%, and 21.6% in patients with low, intermediate, and high SYNTAX score tertiles, respectively. Higher SYNTAX scores significantly predicted a higher risk of MACE (hazard ratio = 2.36; P = 0.02) even after adjustment for potential confounders. The main predictors of MACE were SYNTAX score, advanced age, hyperlipidemia, presentation as recent ST-elevation MI, number of total lesions, and history of renal failure.

Conclusion: The SYNTAX score could predict major cardiac outcomes following PCI in patients with three-vessel disease.

Keywords: Coronary artery disease; SYNTAX score; major adverse cardiac events; mortality; percutaneous coronary intervention.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Kaplan–Meier estimates of the total death-free survival (a) total nonfatal myocardial infarction-free survival (b) total target vessel revascularization-free survival (c) and total major adverse cardiac events-free survival (d) according to the SYNTAX score tertiles
See this image and copyright information in PMC

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