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Meta-Analysis
. 2015:15:1096.
doi: 10.1186/s12885-015-1096-1. Epub 2015 Mar 5.

The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis

Shao-Kai Zhang  1 , Lan-Wei Guo, Qiong Chen, Meng Zhang, Shu-Zheng Liu, Pei-Liang Quan, Jian-Bang Lu, Xi-Bin Sun
Affiliations
Meta-Analysis

The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis

Shao-Kai Zhang et al. BMC Cancer. 2015.

Abstract

Background: The role of human papillomavirus (HPV) in the development of esophageal cancer remains controversial. Our study aims to test the association between HPV 16 infection and esophageal cancer in China, providing useful information on this unclear association in Chinese population.

Methods: Studies on HPV infection and esophageal cancer were identified. A random-effects model was used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) comparing cases with controls.

Results: A total of 1442 esophageal cancer cases and 1602 controls from 10 included studies were evaluated to estimate the association between HPV 16 infection and esophageal cancer risk. The ORs for each case-control studies ranged from 3.65 (95% CI: 2.17, 6.13) to 15.44 (95% CI: 3.42, 69.70). The pooled estimates for OR was 6.36 (95% CI: 4.46, 9.07). In sensitivity analysis, the estimates for OR ranged from 5.92 (95% CI: 4.08, 8.60) to 6.97 (95% CI: 4.89, 9.93).

Conclusions: This study indicates that HPV-16 infection may be a risk factor for esophageal cancer among Chinese population, supporting an etiological role of HPV16 in this malignancy. Results in this study may have important implications for esophageal cancer prevention and treatment in China.

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Figures

Figure 1
Figure 1
Flow diagram for the selection of included studies.
Figure 2
Figure 2
Forest plot for meta-analysis of the association of HPV with esophageal cancer in 10 case–control studies.
Figure 3
Figure 3
Cumulative meta-analysis of case control studies for the evidence of association between HPV and esophageal cancer.
Figure 4
Figure 4
Sensitivity analysis for individual studies on the summary effect.
See this image and copyright information in PMC

References

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