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. 2015 May 21;13(19):5385-90.
doi: 10.1039/c5ob00318k.

Peptide-DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

Elena Pazos  1 , Cecilia Portela, Cristina Penas, M Eugenio Vázquez, José L Mascareñas
Affiliations

Peptide-DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

Elena Pazos et al. Org Biomol Chem. .

Abstract

We describe a ds-oligonucleotide-peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of AP-1-mediated gene expression pathways.

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