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. 2015 Apr;115(1):63-6.
doi: 10.1016/j.radonc.2015.02.020. Epub 2015 Mar 13.

A novel method for delineation of oral mucosa for radiotherapy dose-response studies

Jamie A Dean  1 , Liam C Welsh  2 , Sarah L Gulliford  3 , Kevin J Harrington  2 , Christopher M Nutting  2
Affiliations

A novel method for delineation of oral mucosa for radiotherapy dose-response studies

Jamie A Dean et al. Radiother Oncol. 2015 Apr.

Abstract

There is currently no standard method for delineating the oral mucosa and most attempts are oversimplified. A new method to obtain anatomically accurate contours of the oral mucosa surfaces was developed and applied to 11 patients. This is expected to represent an opportunity for improved toxicity modelling of oral mucositis.

Keywords: Contouring; Delineation; Dose–response; Oral mucosa; Oral mucositis.

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Figures

Fig. 1
Fig. 1
CT scan of a head and neck radiotherapy patient with the OCC (top) and MSC (bottom) shown in green. The OCC representation reduces the complex shape of the mucosal wall to a simplified solid volume, whereas the MSC structure is represented as a mucosal surface and, as such, represents a more anatomically realistic description of the oral mucosa.
Fig. 2
Fig. 2
Median dose–volume histograms for the oral mucosa for the 11 patients using the OCC (dashed line) and MSC (solid line) delineation approach. The shaded areas represent the ranges. The darker shaded area shows the overlap between the ranges.
See this image and copyright information in PMC

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