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. 2015 Mar 17;7(1):29.
doi: 10.1186/s13195-015-0115-4. eCollection 2015.

Kidney disease as a determinant of cognitive decline and dementia

Thorleif Etgen  1
Affiliations

Kidney disease as a determinant of cognitive decline and dementia

Thorleif Etgen. Alzheimers Res Ther. .

Abstract

Chronic kidney disease (CKD) has evolved as a possible new determinant of cognitive decline and dementia. This review outlines the presumed pathophysiology of cognitive decline in CKD, which consists of traditional and new vascular risk factors as well as nonvascular risk factors and metabolic and biochemical abnormalities within the central nervous system caused by CKD. The recent major cross-sectional studies and longitudinal studies - including one meta-analysis - that mostly suggest an association of cognitive decline and CKD are discussed. Finally, potential therapeutic strategies are presented.

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Figures

Figure 1
Figure 1
Pathophysiology of cognitive decline in patients with chronic kidney disease.
See this image and copyright information in PMC

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