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. 2015 Mar 7;8(1):9.
doi: 10.1186/s40413-014-0047-7. eCollection 2015.

Intralymphatic immunotherapy

Gabriela Senti  1 , Thomas M Kündig  2
Affiliations

Intralymphatic immunotherapy

Gabriela Senti et al. World Allergy Organ J. .

Abstract

Gold Standard allergen-specific immunotherapy is associated with low efficacy because it requires either many subcutaneous injections of allergen or even more numerous sublingual allergen administrations to achieve amelioration of symptoms. Intralymphatic vaccination can maximize immunogenicity and hence efficacy. We and others have demonstrated that as few as three low dose intralymphatic allergen administrations are sufficient to effectively alleviate symptoms. Results of recent prospective and controlled trials suggest that this strategy may be an effective form of allergen immunotherapy.

Keywords: Administration routes; Allergen immunotherapy; Intralympathic; Vaccination.

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Figures

Figure 1
Figure 1
Biodistribution after intralymphatic administration. Biodistribution of 99mTc-labelled human IgG after intralymphatic (left abdominal side) and subcutaneous (right abdominal side) injections. Radio tracing was made by gamma-imaging 20 min (left panel) and 25 hours (right panel) after injection. Arrows indicate the site of injection (s.c., subcutaneous, i.l., intralymphatic).
Figure 2
Figure 2
Intralymphatic injection. A sand blasted needle, being inserted into the lymph node from the right was used for better reflection and therefore visibility in the ultrasound. The dark, hypoechoic area represents the paracortex of the lymph node, which is approx. 15 mm long and 5 mm under the skin surface.
See this image and copyright information in PMC

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