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. 2012 Mar;15(1):12-7.
doi: 10.3831/KPI.2012.15.1.012.

Effects of atractylodis rhizoma pharmacopuncture on an acute gastric mucosal lesion induced by compound 48/80 in rats

Yun-Kyu Lee  1 , Jae-Soo Kim  1 , Seong-Chul Lim  1
Affiliations

Effects of atractylodis rhizoma pharmacopuncture on an acute gastric mucosal lesion induced by compound 48/80 in rats

Yun-Kyu Lee et al. J Pharmacopuncture. 2012 Mar.

Abstract

Objectives: This study was designed to investigate the protective effects of Atractylodis Rhizoma pharmacopuncture (ARP) against acute gastric mucosal lesions induced by compound 48/80 in rats.

Methods: The ARP was injected in Joksamni (ST36) and Jungwan (CV12) 1 hr before treatment with compound 48/80. The animals were sacrificed under anesthesia 3 hrs after treatment with compound 48/80. The stomachs were removed, and the amounts of gastric adherent mucus, gastric mucosal hexosamine, thiobarbituric acid reactive substances (TBARS), xanthine oxidase (XO), and superoxide dismutase (SOD) were measured. Also, histological examination were performed.

Results: Gastric adherent mucus, gastric mucosal hexosamine and histological defects of gastric mucosa declined significantly after ARP treatment. Changes in gastric mucosal TBARS were also reduced by ARP treatment, but this result was not statistically significant. ARP treatment did not change the XO and the SOD activities.

Conclusions: ARP showed protective effects for acute gastric mucosal lesions induced by compound 48/80 in rats. These results suggest that ARP may have protective effects for gastritis.

Keywords: ARP (Atractylodis Rhizoma pharmacopuncture); Acupuncture; Acute gastric mucosal lesion; Compound 48/80; Joksamni (ST36); Jung-wan (CV12).

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Figures

Fig. 1
Fig. 1. Effect of ARP on the gastric adherent mucus content in rats with and without a compound 48/80 injection.
Fig. 2
Fig. 2. Effect of ARP on the gastric mucosal hexosamine content in rats with and without a compound 48/80 injection.
Fig. 3
Fig. 3. Photomicrographs of gastric mucosal tissues.
Fig. 4
Fig. 4. Effect of ARP on the gastric mucosal TBARS content in rats with and without a compound 48/80 injection.
Fig. 5
Fig. 5. Effect of ARP on the gastric mucosal XO activity in rats with and without a compound 48/80 injection.
Fig. 6
Fig. 6. Effect of ARP on the gastric mucosal SOD activity in rats with and without a compound 48/80 injection.
See this image and copyright information in PMC

References

    1. Lee EL, Feldman M. Gastritis and other gastropathies. In: Feldmman M, Friedman LS, Sleigenger MH, eds. Sleigenger & Fordtran's gastrointestinal and liver disease. 7th ed. WB Saunders Company; Philadelphia: 2002. pp. 810–827.
    1. Cho SY, Lee SH, Choi JY, Shin EM, Kang SS, Jeong SJ et al. Antigastric effect of carbenoxolone disodium from glycyrrhizae radix. J Toxical Pub Health. 2007;23(2):165–172.
    1. Kim IR, Kim HC, Kuk YB, Park SJ, Park YK, Park JH Boncho-Hak. Young-Lim Press; Seoul: 2007. pp. 331–332.
    1. Enerbäck L, Lundin PM .ck L, Lundin PM. Ultrastructure of mucosal mast cells in normal and compound 48-80-treated rats. Cell Tissue Res. 1974;150(1):95–105. - PubMed
    1. Irman-Florjanc T, Erjavec F. Compound 48/80 and substance P-induced release of histamine and serotonin from rat peritoneal mast cells. Agents Actions. 1983;13(2-3):138–141. doi: 10.1007/BF01967317. - DOI - PubMed

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