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. 2015 May 15;29(8):977-9.
doi: 10.1097/QAD.0000000000000643.

Telaprevir decreases estimated glomerular filtration rate in HIV-hepatitis C virus coinfected patients

Eva Van den Eynde  1 , Jordi Curto, Elena Ferrer, Arkaitz Imaz, Maria Saumoy, Silvana Di Yacovo, Antonia Vila, Daniel Podzamczer
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Telaprevir decreases estimated glomerular filtration rate in HIV-hepatitis C virus coinfected patients

Eva Van den Eynde et al. AIDS. .

Abstract

We investigated kidney function outcome in 24 chronic hepatitis C genotype 1 patients coinfected with HIV receiving telaprevir in a single tertiary care hospital in Spain. A statistically significant median (interquartile range) decrease in estimated glomerular filtration rate (eGFR, ml/min/1.73 m) relative to baseline [93.6 (73.0-109.0)] was seen at weeks 4 [86.5 (34.0-112.0), P = 0.014], 8 [90.0 (49.0-111.0), P = 0.026] and 12 [89.5 (54.0-113.0), P = 0.017]. These changes reversed after telaprevir discontinuation. Patients presenting an eGFR decrease had a higher risk of haematological toxicity.

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