Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jun;62(2):234-52.
doi: 10.1007/s12026-015-8640-6.

Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility

Mamoona Noreen  1 , Muhammad Arshad
Affiliations
Review

Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility

Mamoona Noreen et al. Immunol Res. 2015 Jun.

Abstract

Toll like receptors (TLRs) play a crucial role in regulation of innate as well as adaptive immunity. TLRs recognize a distinct but limited repertoire of conserved microbial products. Ligand binding to TLRs activates the signaling cascade and results in activation of multiple inflammatory genes. Variation in this immune response is under genetic control. Polymorphisms in genes associated with inflammatory pathway especially influence the outcome of diseases. TLR2 makes heterodimer with TLR1 or TLR6 and recognizes a wide variety of microbial ligands. In this review, we summarize studies of polymorphisms in genes encoding TLR1, TLR2, TLR4, TLR6, and most polymorphic adaptor protein, Mal/TIRAP, revealing their effect on susceptibility to diseases.

PubMed Disclaimer

References

    1. Mol Biol Rep. 2012 Dec;39(12):10795-802 - PubMed
    1. Pediatr Infect Dis J. 2003 Nov;22(11):1018-9 - PubMed
    1. Science. 2004 Mar 5;303(5663):1522-6 - PubMed
    1. Infect Genet Evol. 2008 Sep;8(5):541-4 - PubMed
    1. J Infect Dis. 2008 Jan 15;197(2):253-61 - PubMed

MeSH terms

LinkOut - more resources