Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jan 15;8(1):1-9.
eCollection 2015.

Impact of microalbuminuria on incident coronary heart disease, cardiovascular and all-cause mortality: a meta-analysis of prospective studies

Fang Xia  1 , Guanghua Liu  2 , Yifu Shi  1 , Yan Zhang  1
Affiliations
Review

Impact of microalbuminuria on incident coronary heart disease, cardiovascular and all-cause mortality: a meta-analysis of prospective studies

Fang Xia et al. Int J Clin Exp Med. .

Abstract

This study is to investigate the magnitude of relationship between microalbuminuria and incident coronary heart disease (CHD) and mortality in the general population by conducting a meta-analysis. A comprehensive literature search in Pubmed and Embase database was performed prior to March 2014. Only prospective studies investigating the presence of microalbuminuria and incident CHD, cardiovascular disease (CVD), and mortality and were selected. Pooled risk ratio (RR) and 95% confidence interval (CI) were calculated by the presence of microalbuminuria versus without microalbuminuria. Finally, we identified 8 prospective studies involving 114,105 individuals. Participants with microalbuminuria were associated with 69% greater risk of CVD (RR=1.69; 95% CI 1.41-2.02) and 41% greater risk of CHD (RR=1.41; 95% CI 1.17-1.69). Participants with microalbuminuria were also associated with 57% greater risk of cardiovascular mortality (RR=1.57; 95% CI 1.20-2.06) and 65% greater risk of all-cause mortality (RR=1.65; 95% CI 1.45-1.88). Microalbuminuria is an independent predictor for CHD, CVD, and all-cause mortality in the general population. Early detection of microalbuminuria in the general population is likely to identify patients at increased risk of CVD and mortality.

Keywords: Microalbuminuria; cardiovascular disease; coronary heart disease; meta-analysis; mortality.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow chart of study selection process for meta-analysis.
Figure 2
Figure 2
RR and 95% CI from the eligible studies of coronary heart disease and cardiovascular disease comparing the microalbuminuria to without microalbuminuria in a random effect model.
Figure 3
Figure 3
RR and 95% CI from the eligible studies of cardiovascular mortality comparing the microalbuminuria to without microalbuminuria in a random effect model.
Figure 4
Figure 4
RR and 95% CI from the eligible studies of all-cause mortality comparing microalbuminuria to without microalbuminuria in a fixed-effect model.
See this image and copyright information in PMC

References

    1. Ovbiagele B. Microalbuminuria: risk factor and potential therapeutic target for stroke? J Neurol Sci. 2008;271:21–28. - PubMed
    1. Yuyun MF, Khaw KT, Luben R, Welch A, Bingham S, Day NE, Wareham NJ. A prospective study of microalbuminuria and incident coronary heart disease and its prognostic significance in a British population: the EPIC-Norfolk study. Am J Epidemiol. 2004;159:284–293. - PubMed
    1. Wang Z, Hoy WE. Albuminuria and incident coronary heart disease in Australian Aboriginal people. Kidney Int. 2005;68:1289–1293. - PubMed
    1. Tillin T, Forouhi N, McKeigue P, Chaturvedi N. Microalbuminuria and coronary heart disease risk in an ethnically diverse UK population: a prospective cohort study. J Am Soc Nephrol. 2005;16:3702–3710. - PubMed
    1. Diercks GF, van Boven AJ, Hillege HL, Janssen WM, Kors JA, de Jong PE, Grobbee DE, Crijns HJ, van Gilst WH. Microalbuminuria is independently associated with ischaemic electrocardiographic abnormalities in a large non-diabetic population. The PREVEND (Prevention of REnal and Vascular ENdstage Disease) study. Eur Heart J. 2000;21:1922–1927. - PubMed

LinkOut - more resources