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. 2015 Jan 15;8(1):73-85.
eCollection 2015.

Meta-analysis of studies on breast cancer risk and diet in Chinese women

Ying-Chao Wu  1 , Dong Zheng  2 , Jin-Jie Sun  3 , Zhi-Kang Zou  3 , Zhong-Li Ma  3
Affiliations

Meta-analysis of studies on breast cancer risk and diet in Chinese women

Ying-Chao Wu et al. Int J Clin Exp Med. .

Abstract

Objective: A meta-analysis was carried out to summarize published data on the relationship between breast cancer and dietary factors.

Methods: Databases in Chinese (China National Knowledge Infrastructure [CNKI], China Biology Medicine [CBM], WanFang, VIP) and in English (PubMed and Web of Science) were searched for articles analyzing vegetable, fruit, soy food and fat consumption and breast cancer risk published through June 30, 2013. Random effects models were used to estimate summary odds ratios (OR) based on high versus low intake, and subgroup analysis was conducted according to region, study design, paper quality and adjustment for confounding factors to detect the potential source of heterogeneity. Every study was screened according to the inclusion criteria and exclusion criteria, evaluated in accordance with the Newcastle-Ottawa Scale. RevMan 5.2 software was used for analysis.

Results: Of 785 studies retrieved, 22 met inclusion criteria (13 in Chinese and 9 in English), representing 23,201 patients: 10,566 in the experimental group and 12,635 in the control group. Thirteen included studies showed vegetables consumption to be a relevant factor in breast cancer risk, OR = 0.77 (95% CI [confidence interval] 0.62-0.96). Eleven studies showed fruits consumption to be relevant, OR = 0.68 (95% CI 0.49-0.93). Significant differences were also found between those who consumed soy foods, OR = 0.68 (95% CI 0.50-0.93) and those who ate a high-fat diet, OR = 1.15 (95% CI 1.01-1.30).

Conclusion: This analysis confirms the association between intake of vegetables, fruits, soy foods and fat and the risk of breast cancer from published sources. It's suggested that high consumption of vegetables, fruits and soy foods may reduce the risk of breast cancer, while increasing fat consumption may increase the risk.

Keywords: Breast cancer; dietary factor; meta-analysis.

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Figures

Figure 1
Figure 1
Flow diagram for search results.
Figure 2
Figure 2
The Odd Ratio of vegetables and breast cancer risk in Chinese women (high vs. low intake).
Figure 3
Figure 3
The funnel plot of related articles on vegetables.
Figure 4
Figure 4
The Odd Ratio of fruits and breast cancer risk in Chinese women (high vs. low intake).
Figure 5
Figure 5
The funnel plot of related articles of fruits.
Figure 6
Figure 6
The Odd Ratio of soy foods and breast cancer in Chinese women (high vs. low intake).
Figure 7
Figure 7
The funnel plot of related articles of soy foods.
Figure 8
Figure 8
The Odd Ratio of intake of fat and breast cancer risk in Chinese women (high vs. low intake).
Figure 9
Figure 9
The funnel plot of related articles of fat.
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