Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan 15;8(1):764-9.
eCollection 2015.

The roles of vitamin B12 and vitamin D in children with intractable epilepsy

Xiao-Hong Li  1 , Xiao-Yan Hou  2 , Rong Chen  1
Affiliations

The roles of vitamin B12 and vitamin D in children with intractable epilepsy

Xiao-Hong Li et al. Int J Clin Exp Med. .

Abstract

Epilepsy is a chronic neurological disorder. Antiepileptic drugs (AEDs) can cause vitamin B12 or D deficiency in children with intractable epilepsy. In this study, we measured salivary superoxide dismutase (SOD) and metalloproteinsases (MMP) levels in the patients with vitamin B12 and vitamin D treatment. Cytokines and chemokines were measured using ELISA. The mean salivary value of SOD activity in the control group was 1.75 ± 0.21 U/ml. In the treatment group, the value was 1.33 ± 0.18 U/ml. The salivary MMP 2, MMP 3, and MMP 9 levels of the patients with vitamin D and vitamin B12 treatment were lower than that in the patients without vitamin D and vitamin B12 treatment. Interleukin 1β (IL-1β), IL-6, IL-8, macrophage inflammatory protein 1β (MIP-1β), monocyte chemoattractant protein-1 (MCP-1) and IFN-inducible protein 10 (IP-10) were significantly decreased in the cortex of our patients with vitamin D and vitamin B12 treatment. In this study, a clear association between vitamin D and vitamin B12 treatment and epilepsy was identified. We now plan to investigate the genetic factors that underlie vitamin D and vitamin B12 treatment in patients treated with AEDs.

Keywords: MMP; Vitamin D; antiepileptic drugs; cytokines; vitamin B12.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Serum levels of vitamin D (A) and vitamin B12 (B) were measured by using ELISA.
Figure 2
Figure 2
Salivary SOD (A) and metalloproteinases (MMP) activity (B) were measured as described in Methods.
Figure 3
Figure 3
Activation maps for the left temporal lobe epilepsy (LTLE) and right temporal lobe epilepsy (RTLE) in the patients with or without vitamin D and vitamin B12 treatment.
Figure 4
Figure 4
Cytokine analysis by ELISA. IL-1β (A), IL-6 (B), IL-8 (C), MIP-1β (D), MCP-1 (E) and IP-10 (F) were significantly decreased in brains of patients with epilepsy after vitamin D and vitamin B12 treatment.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Folbergrová J, Kunz WS. Mitochondrial dysfunction in epilepsy. Mitochondrion. 2012;12:35–40. - PubMed
    1. Loscher W, Schmidt D. Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia. 2011;52:657–678. - PubMed
    1. Hanai T. Quality of life in children with epilepsy. Epilepsia. 1996;37:28–32. - PubMed
    1. McEwan MJ, Espie CA, Metcalfe J, Brodie MJ, Wilson MT. A systematic review of the contribution of qualitative research to the study of quality of life in children and adolescents with epilepsy. Seizure. 2004;13:3–14. - PubMed
    1. Linnebank M, Moskau S, Semmler A, Widman G, Stoffel-Wagner B, Weller M, Elger CE. Antiepileptic drugs interact with folate and vitamin B12 serum levels. Ann Neurol. 2011;69:352–359. - PubMed

LinkOut - more resources