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. 2015 Jan 15;8(1):944-8.
eCollection 2015.

Angiotensin-converting enzyme I/D polymorphism is a genetic biomarker of diabetic peripheral neuropathy: evidence from a meta-analysis

Weiguo Xu  1 , Yunfeng Qian  1 , Luqian Zhao  2
Affiliations

Angiotensin-converting enzyme I/D polymorphism is a genetic biomarker of diabetic peripheral neuropathy: evidence from a meta-analysis

Weiguo Xu et al. Int J Clin Exp Med. .

Abstract

The Angiotensin-converting enzyme (ACE) I/D polymorphism has been indicated to be correlated with peripheral neuropathy (PN) susceptibility, but study results are still debatable. Thus, a meta-analysis was conducted. Databases including PubMed, Embase and CNKI were searched. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Eight studies with 1430 cases and 1873 controls were included in this meta-analysis. The association between ACE I/D polymorphism and PN risk was significant (OR = 1.25; 95% CI 1.05-1.48; P = 0.01). When stratified by ethnicity, the significantly increased PN risk was observed in Caucasians (OR = 1.24; 95% CI 1.05-1.47; P = 0.01). In conclusion, this meta-analysis suggested that ACE I/D polymorphism was a risk factor for PN.

Keywords: Angiotensin-converting enzyme; genetics; meta-analysis; peripheral neuropathy.

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Figures

Figure 1
Figure 1
Flow of study identification, inclusion, and exclusion.
Figure 2
Figure 2
Meta-analysis for the association between the ACE I/D polymorphisma nd DPN risk.
Figure 3
Figure 3
Cumulative meta-analysis for association between the ACE I/D polymorphism and DPN risk.
See this image and copyright information in PMC

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