The plasma and platelet are important in reducing the mortality in surgical massive blood transfusion: a large multicenter study in China

Abstract

Objective: The aim of this study was to learn the current situation of surgical massive transfusion of death and survival groups in China, which could provide the basis for the formulation of guidelines on massive transfusion.

Methods: A multicenter retrospective research for the application status of blood constituents during massive blood transfusion was conducted, the differences of fresh frozen plasma and platelet application between death group and survival group were compared, and the transfusion volume and the distribution of other blood constituents were analyses at different periods of time when red blood cells are infused between death group and survival group.

Results: The patients with fresh frozen plasma compare the patients with red blood cell was 1:1-2 during massive transfusion, while the dosage of platelet and cryocepitate were transfused very small. Results showed that the average amount of platelet and plasma in death group was significantly lower than those in survival group.

Conclusion: During massive transfusion, clinicians in 20 Chinese hospitals paid more attention to the infusion of fresh frozen plasma while making the infusion of red blood cells. However, they paid little attention to the supplement of platelet and cryocepitate. The average quantity of plasma and platelet in survival group were also higher than those in death group.

Keywords: Massive transfusion; blood constituents; plasma; platelet.

Figure 1

The plasma transfusion in the death group and survival group under different dosage of RBC. A. The ratio of the patients with pRBC transfusion compare with the patients with plasma transfusion in the death group and survival group. B. The mean dosage of plasma in the death group and survival group. The mean dosage of plasma = the amount of plasma/the number of the patients with plasma infusion.

Figure 2

plasma transfusion in the death group and survival group under different dosage of RBC. A. The mean dosage of platelets infusion in the death group and survival group. The mean dosage of platelets = the amount of platelets/the number of the patients with platelets infusion. B. The mean dosage of cryoprecipitate infusion in in the death group and survival group. The mean dosage of cryoprecipitate = the amount of cryoprecipitate/the number of the patients with cryoprecipitate infusion.