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Comment
. 2015 Mar 17;42(3):393-4.
doi: 10.1016/j.immuni.2015.02.017.

A broken krebs cycle in macrophages

Luke A J O'Neill  1
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A broken krebs cycle in macrophages

Luke A J O'Neill. Immunity. .
Free article

Abstract

Macrophages undergo metabolic rewiring during polarization but details of this process are unclear. In this issue of Immunity, Jha et al. (2015) report a systems approach for unbiased analysis of cellular metabolism that reveals key metabolites and metabolic pathways required for distinct macrophage polarization states.

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