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Comment
. 2015 Mar 17;42(3):397-9.
doi: 10.1016/j.immuni.2015.02.016.

HIF1α allows monocytes to take a breather during sepsis

Derek W Gilroy  1 , Simon Yona  2
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HIF1α allows monocytes to take a breather during sepsis

Derek W Gilroy et al. Immunity. .
Free article

Abstract

How the immune system is negatively affected by sepsis is not fully understood. In this issue of Immunity, Shalova et al. (2015) show that during human sepsis monocytes upregulate hypoxia-inducible factor-α (HIF1-α) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties.

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