Infected cells call their killers to the scene of the crime
- PMID: 25786170
- DOI: 10.1016/j.immuni.2015.03.001
Infected cells call their killers to the scene of the crime
Abstract
Effector CD8(+) T cells scan tissues to locate and kill infected host cells. In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates clearance of epicutaneous vaccinia virus infection.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells.Immunity. 2015 Mar 17;42(3):524-37. doi: 10.1016/j.immuni.2015.02.009. Epub 2015 Mar 10. Immunity. 2015. PMID: 25769612 Free PMC article.
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