Cigarette smoke resets the Alarmin IL-33 in COPD
- PMID: 25786171
- DOI: 10.1016/j.immuni.2015.02.014
Cigarette smoke resets the Alarmin IL-33 in COPD
Abstract
Cigarette smoke and infection are the major drivers of chronic obstructive pulmonary disease. In this issue of Immunity, Kearley et al. (2015) demonstrate that smoke exposure alters the lung microenvironment leading to an interleukin-33-dependent proinflammatory disease exacerbation.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection.Immunity. 2015 Mar 17;42(3):566-79. doi: 10.1016/j.immuni.2015.02.011. Immunity. 2015. PMID: 25786179
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