CNS injury: IL-33 sounds the alarm
- PMID: 25786172
- DOI: 10.1016/j.immuni.2015.02.019
CNS injury: IL-33 sounds the alarm
Abstract
Central nervous system trauma induces marked inflammation that has beneficial and deleterious consequences. In a recent issue of Neuron, Gadani et al. (2015) show that injured spinal cord releases the alarmin IL-33 to drive chemokines that recruit monocytes and promote recovery.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury.Neuron. 2015 Feb 18;85(4):703-9. doi: 10.1016/j.neuron.2015.01.013. Epub 2015 Feb 5. Neuron. 2015. PMID: 25661185 Free PMC article.