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. 1985 Jan;82(2):552-5.
doi: 10.1073/pnas.82.2.552.

Murine monoclonal antibodies to the myelin-associated glycoprotein react with large granular lymphocytes of human blood

M J Dobersen, P Gascon, S Trost, J A Hammer, S Goodman, A B Noronha, D J O'Shannessy, R O Brady, R H Quarles

Murine monoclonal antibodies to the myelin-associated glycoprotein react with large granular lymphocytes of human blood

M J Dobersen et al. Proc Natl Acad Sci U S A. 1985 Jan.

Abstract

Monoclonal antibodies prepared to human myelin-associated glycoprotein were shown to react with a population of human peripheral blood mononuclear cells. The population is similar to the large granular lymphocytes or natural killer cells defined by antibody Leu 7 (also called HNK-1). The population also includes cells exhibiting the Leu 2 marker for suppressor/cytotoxic T cells. The results indicate a shared antigenicity between the nervous system and the immune system and may be relevant to the pathogenesis of demyelinating diseases.

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