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Review
. 2015 Apr;5(2):101-15.
doi: 10.1007/s13346-013-0135-1.

Clinical translation of controlled protein delivery systems for tissue engineering

Kara L Spiller  1 , Gordana Vunjak-Novakovic
Affiliations
Review

Clinical translation of controlled protein delivery systems for tissue engineering

Kara L Spiller et al. Drug Deliv Transl Res. 2015 Apr.

Abstract

Strategies that utilize controlled release of drugs and proteins for tissue engineering have enormous potential to regenerate damaged organs and tissues. The multiple advantages of controlled release strategies merit overcoming the significant challenges to translation, including high costs and long, difficult regulatory pathways. This review highlights the potential of controlled release of proteins for tissue engineering and regenerative medicine. We specifically discuss treatment modalities that have reached preclinical and clinical trials, with emphasis on controlled release systems for bone tissue engineering, the most advanced application with several products already in clinic. Possible strategies to address translational and regulatory concerns are also discussed.

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Figures

Figure 1
Figure 1
FDA regulatory path for tissue-engineering devices in regenerative medicine
See this image and copyright information in PMC

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