Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Apr;9(4):1502-1508.
doi: 10.3892/ol.2015.2959. Epub 2015 Feb 12.

Biomarkers for gastric cancer: Progression in early diagnosis and prognosis (Review)

Ziliang Jin  1 , Weihua Jiang  1 , Liwei Wang  1
Affiliations

Biomarkers for gastric cancer: Progression in early diagnosis and prognosis (Review)

Ziliang Jin et al. Oncol Lett. 2015 Apr.

Abstract

Gastric cancer is one of leading causes of cancer-related mortality worldwide and is a notable disease due to its heterogeneity. Recently, numerous studies have investigated the molecular basis of gastric cancer, involving the alteration of pathogenesis, and invasion and metastasis. With the development of modern technologies, various novel biomarkers had been identified that appear to possess diagnostic and prognostic value; therefore, the present review describes our current knowledge of biomarkers for the early diagnosis and prognosis of gastric cancer. Classic biomarkers for gastric cancer diagnosis include carcinoembryonic antigen and cancer antigen 19-9, while microRNA and DNA hypomethylation are proposed as novel biomarkers. Excluding classical biomarkers, biomarkers for determining the progression and prognosis of gastric cancer focus on targeting microRNAs, epigenetic alterations and genetic polymorphisms.

Keywords: biological marker; early diagnosis; gastric cancer; prognosis.

PubMed Disclaimer

References

    1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90. doi: 10.3322/caac.20107. - DOI - PubMed
    1. Hu B, El Hajj N, Sittler S, et al. Gastric cancer: Classification, histology and application of molecular pathology. J Gastrointest Oncol. 2012;3:251–261. - PMC - PubMed
    1. Nitti D, Mocellin S, Marchet A, Pilati P, Lise M. Recent advances in conventional and molecular prognostic factors for gastric carcinoma. Surg Oncol Clin N Am. 2008;17:467–483. doi: 10.1016/j.soc.2008.02.010. - DOI - PubMed
    1. Resende C, Ristimäki A, Machado JC. Genetic and epigenetic alteration in gastric carcinogenesis. Helicobacter. 2010;15:34–39. doi: 10.1111/j.1523-5378.2010.00782.x. - DOI - PubMed
    1. Pectasides D, Mylonakis A, Kostopoulou M, et al. CEA, CA 19–9, and CA-50 in monitoring gastric carcinoma. Am J Clin Oncol. 1997;20:348–353. doi: 10.1097/00000421-199708000-00005. - DOI - PubMed