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Randomized Controlled Trial
. 2015 Feb;70(2):102-6.
doi: 10.6061/clinics/2015(02)06.

Improvement in medication adherence and self-management of diabetes with a clinical pharmacy program: a randomized controlled trial in patients with type 2 diabetes undergoing insulin therapy at a teaching hospital

Catarina Gomes Cani  1 , Laura da Silva Girão Lopes  1 , Márcia Queiroz  1 , Márcia Nery  1
Affiliations
Randomized Controlled Trial

Improvement in medication adherence and self-management of diabetes with a clinical pharmacy program: a randomized controlled trial in patients with type 2 diabetes undergoing insulin therapy at a teaching hospital

Catarina Gomes Cani et al. Clinics (Sao Paulo). 2015 Feb.

Abstract

Objective: To evaluate the impact of a clinical pharmacy program on health outcomes in patients with type 2 diabetes undergoing insulin therapy at a teaching hospital in Brazil.

Method: A randomized controlled trial with a 6-month follow-up period was performed in 70 adults, aged 45 years or older, with type 2 diabetes who were taking insulin and who had an HbA1c level ≥8%. Patients in the control group (CG) (n = 36) received standard care, patients in the intervention group (IG) (n = 34) received an individualized pharmacotherapeutic care plan and diabetes education. The primary outcome measure was change in HbA1c. Secondary outcomes included diabetes and medication knowledge, adherence to medication, insulin injection and home blood glucose monitoring techniques and diabetes-related quality of life. Outcomes were evaluated at baseline and 6 months using questionnaires.

Results: Diabetes knowledge, medication knowledge, adherence to medication and correct insulin injection and home blood glucose monitoring techniques significantly improved in the intervention group but remained unchanged in the control group. At the end of the study, mean HbA1c values in the control group remained unchanged but were significantly reduced in the intervention group. Diabetes-related quality of life significantly improved in the intervention group but worsened significantly in the control group.

Conclusion: The program improved health outcomes and resulted in better glycemic control in patients with type 2 diabetes undergoing insulin therapy.

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Conflict of interest statement

No potential conflict of interest was reported.

Figures

Figure 1
Figure 1
Flow chart showing the various phases of the study.
See this image and copyright information in PMC

References

    1. International Diabetes Federation. 2011 IDF Diabetes Atlas, (cited 2011 Dec 12);5:(Available from: http://www.idf.org/diabetesatlas/5e/the-global-burden).
    1. Brasil, Ministério da Saúde. Vigitel Brasil 2011, (cited 2012 Jul 12); (Available from: http://portalsaude.saude.gov.br/portalsaude/arquivos/pdf/2012/Mai/09/Vig...).
    1. Lindenmeyer A, Hearnshaw H, Vermeire E, Royen PV, Wens J, Biot Y. Interventions to improve adherence to medication in people with type 2 diabetes mellitus: a review of the literature on the role of pharmacists. J Clin Pharm Ther. 2006;31(5):409–19. - PubMed
    1. Standards of Medical Care in Diabetes. Diabetes Care. 2012;35(Suppl 1):S11–63. - PMC - PubMed
    1. Sisson E, Kuhn C. Pharmacist roles in the management of patients with type 2 diabetes. J Am Pharm Assoc. 2009;49(Suppl 1):S41–5. - PubMed

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