Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985;69(2):151-6.
doi: 10.1007/BF00293287.

Intercellular NOR-Ag-variability in man. II. Search for determining factors, clonal analysis

O A Sozansky, A F Zakharov, S M Terekhov

Intercellular NOR-Ag-variability in man. II. Search for determining factors, clonal analysis

O A Sozansky et al. Hum Genet. 1985.

Abstract

Intercellular, nonartifactual variability of nucleolar organizer region (NOR)-Ag-staining was studied in cultured human peripheral blood lymphocytes, skin and embryonic fibroblasts. No differences in number and character of variable NORs and intensity of their staining were observed between lymphocytes stimulated to proliferate with phytohemagglutinin and pokeweed mitogen, as well as lymphocytes of first- and second division. The number of NOR associations per cell and the number of associated chromosomes per association were also similar. In a given individual these criteria were similar in lymphocytes and fibroblasts. In all nine clones derived from three independent parental fibroblast cultures the intercellular NOR-Ag-variability was similar to that observed in a given parental cell line. A significant decrease in the number of metaphases containing NOR associations was observed in second-division lymphocytes compared with first-division ones, as well as in skin fibroblasts compared with lymphocytes.

PubMed Disclaimer

References

    1. Hum Genet. 1978 Jun 27;42(3):291-9 - PubMed
    1. Chromosoma. 1981;84(3):345-51 - PubMed
    1. Cytogenet Cell Genet. 1983;35(3):223-5 - PubMed
    1. Tsitologiia. 1970 Dec;12(12):1489-96 - PubMed
    1. Hum Genet. 1979;50(1):81-91 - PubMed