Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2016 Jan;19(1):156-63.
doi: 10.1017/S1368980015000609. Epub 2015 Mar 20.

Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial

Maryam Karamali  1 , Zatollah Asemi  2 , Maedeh Ahmadi-Dastjerdi  1 , Ahmad Esmaillzadeh  3
Affiliations
Randomized Controlled Trial

Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial

Maryam Karamali et al. Public Health Nutr. 2016 Jan.

Expression of concern in

Abstract

Objective: The present study was designed to assess the effects of Ca+vitamin D supplementation on pregnancy outcomes in women with gestational diabetes mellitus (GDM).

Design: A randomized, double-blind, placebo-controlled trial was conducted among sixty women with GDM. Participants were divided into two groups to receive Ca+vitamin D supplements or placebo. Individuals in the Ca+vitamin D group (n 30) received 1000 mg Ca/d and two pearls containing 1250 µg (50 000 IU) of cholecalciferol (vitamin D(3)) during the intervention (one at study baseline and another at day 21 of the intervention); those in the placebo group (n 30) received two placebos of vitamin D at the mentioned times and placebos of Ca every day for 6 weeks. Pregnancy outcomes were determined.

Setting: A urban community setting in Arak, Iran.

Subjects: Sixty women with GDM and their newborns, living in Arak, Iran were enrolled.

Results: Women treated with Ca+vitamin D had a significant decrease in caesarean section rate (23·3 % v. 63·3 %, P=0·002) and maternal hospitalization (0 v. 13·3 %, P=0·03) compared with those receiving placebo. In addition, newborns of GDM women randomized to Ca+vitamin D had no case of macrosomia, while the prevalence of macrosomia among those randomized to placebo was 13·3 % (P=0·03). Lower rates of hyperbilirubinaemia (20·0 % v. 56·7 %, P=0·03) and hospitalization (20·0 % v. 56·7 %, P=0·03) were also seen in the supplemented group of newborns than in the placebo group.

Conclusions: Ca+vitamin D supplementation for 6 weeks among pregnant women with GDM led to decreased caesarean section rate and maternal hospitalization, and decreased macrosomia, hyperbilirubinaemia and hospitalization in newborns.

Keywords: Calcium; Gestational diabetes mellitus; Pregnancy outcomes; Supplementation; Vitamin D.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Summary of patient flow in the present randomized, double-blind, placebo-controlled trial (GDM, gestational diabetes mellitus)
See this image and copyright information in PMC

References

    1. Prutsky GJ, Domecq JP, Sundaresh V et al.. (2013) Screening for gestational diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab 98, 4311–4318. - PubMed
    1. Karcaaltincaba D, Kandemir O, Yalvac S et al.. (2009) Prevalence of gestational diabetes mellitus and gestational impaired glucose tolerance in pregnant women evaluated by National Diabetes Data Group and Carpenter and Coustan criteria. Int J Gynaecol Obstet 106, 246–249. - PubMed
    1. Owens LA, O’Sullivan EP, Kirwan B et al.. (2010) ATLANTIC DIP: the impact of obesity on pregnancy outcome in glucose-tolerant women. Diabetes Care 33, 577–579. - PMC - PubMed
    1. HAPO Study Cooperative Research Group (2010) Hyperglycaemia and Adverse Pregnancy Outcome (HAPO) Study: associations with maternal body mass index. BJOG 117, 575–584. - PubMed
    1. Coustan DR (2014) Diagnosis of gestational diabetes. Scand J Clin Lab Invest Suppl 74, 27–33. - PubMed

Publication types

MeSH terms