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. 2015 May;407(12):3271-5.
doi: 10.1007/s00216-015-8610-9. Epub 2015 Mar 20.

Surface-enhanced Raman spectroscopy of urine for prostate cancer detection: a preliminary study

Greta Del Mistro  1 , Silvia Cervo, Elena Mansutti, Riccardo Spizzo, Alfonso Colombatti, Pietro Belmonte, Renzo Zucconelli, Agostino Steffan, Valter Sergo, Alois Bonifacio
Affiliations
Free article

Surface-enhanced Raman spectroscopy of urine for prostate cancer detection: a preliminary study

Greta Del Mistro et al. Anal Bioanal Chem. 2015 May.
Free article

Abstract

Surface-enhanced Raman scattering (SERS) spectra were obtained from urine samples from subjects diagnosed with prostate cancer as well as from healthy controls, using Au nanoparticles as substrates. Principal component analysis (PCA) of the spectral data, followed by linear discriminant analysis (LDA), leads to a classification model with a sensitivity of 100 %, a specificity of 89 %, and an overall diagnostic accuracy of 95 %. Even considering the very limited number of samples involved in this report, preliminary results from this approach are extremely promising, encouraging further investigation.

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