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Comment
. 2015 Mar 20;347(6228):1319-20.
doi: 10.1126/science.aaa9608.

Stem cells. Holding your breath for longevity

Alejandro Ocampo  1 , Juan Carlos Izpisua Belmonte  2
Affiliations
Comment

Stem cells. Holding your breath for longevity

Alejandro Ocampo et al. Science. .
No abstract available

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Figures

Figure 1
Figure 1
SIRT7 metabolic checkpoint regulates hematopoietic stem cell aging (HSCs). (A) In young HSCs, SIRT7 interacts with nuclear respiratory factor 1 (NRF1) repressing the transcription of mitochondrial ribosomal proteins (mRPs) and translational factors (mTFs). This repression results in the suppression of mitochondrial biogenesis and respiration in HSCs. Young HSCs maintain a proper balance of quiescence, proliferation and differentiation between different blood cell types. (B) In old HSCs, SIRT7 expression is reduced, leading to the activation of mRPS and mTFs, increased mitochondrial biogenesis and mitochondrial protein stress. As a consequence of these mitochondrial bursts, old HSCs exit quiescence, increase proliferation and are prone to a myeloid-biased differentiation.
See this image and copyright information in PMC

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