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Comparative Study
. 2015 Jun;42(7):1052-61.
doi: 10.1007/s00259-015-3035-4. Epub 2015 Mar 20.

[(18)F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease

Ryuichi Harada  1 , Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Kotaro Hiraoka, Shoichi Watanuki, Miho Shidahara, Masayasu Miyake, Yoichi Ishikawa, Rin Matsuda, Akie Inami, Takeo Yoshikawa, Tetsuro Tago, Yoshihito Funaki, Ren Iwata, Manabu Tashiro, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo
Affiliations
Comparative Study

[(18)F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease

Ryuichi Harada et al. Eur J Nucl Med Mol Imaging. 2015 Jun.

Abstract

Purpose: Visualization of the spatial distribution of neurofibrillary tangles would help in the diagnosis, prevention and treatment of dementia. The purpose of the study was to evaluate the clinical utility of [(18)F]THK-5117 as a highly selective tau imaging radiotracer.

Methods: We initially evaluated in vitro binding of [(3)H]THK-5117 in post-mortem brain tissues from patients with Alzheimer's disease (AD). In clinical PET studies, [(18)F]THK-5117 retention in eight patients with AD was compared with that in six healthy elderly controls. Ten subjects underwent an additional [(11)C]PiB PET scan within 2 weeks.

Results: In post-mortem brain samples, THK-5117 bound selectively to neurofibrillary deposits, which differed from the binding target of PiB. In clinical PET studies, [(18)F]THK-5117 binding in the temporal lobe clearly distinguished patients with AD from healthy elderly subjects. Compared with [(11)C]PiB, [(18)F]THK-5117 retention was higher in the medial temporal cortex.

Conclusion: These findings suggest that [(18)F]THK-5117 provides regional information on neurofibrillary pathology in living subjects.

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References

    1. J Neurosci. 2005 Nov 23;25(47):10857-62 - PubMed
    1. Biochem Pharmacol. 2014 Apr 15;88(4):529-39 - PubMed
    1. Arch Neurol. 1995 Jan;52(1):81-8 - PubMed
    1. Nat Rev Drug Discov. 2010 May;9(5):387-98 - PubMed
    1. Brain. 2014 Jun;137(Pt 6):1762-71 - PubMed

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