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. 2001;4(1):25-7.
doi: 10.1298/jjpta.4.25.

Effects of treadmill exercise on muscle fibers in mice with steroid myopathy

M Okita  1 , T Yoshimura  2 , J Nakano  3 , M Watabe  1 , T Nagai  4 , K Kato  1 , K Eguchi  5
Affiliations

Effects of treadmill exercise on muscle fibers in mice with steroid myopathy

M Okita et al. J Jpn Phys Ther Assoc. 2001.

Abstract

We studied the effect of treadmill exercise on muscle fibers in mice with experimental steroid myopathy. Frozen sections of the extensor digitorum longus (EDL) and soleus (SOL) muscles were stained with hematoxylin-eosin, and the muscle fiber diameters measured. In the EDL, muscle fiber diameters in the steroid groups decreased significantly compared with those in the control groups; moreover, muscle fiber diameters in the exercise groups increased significantly compared with those in the non-exercise groups, whereas the diameters in the SOL did not differ. We speculate that treadmill exercise may prevent corticosteroid-induced muscle fiber atrophy.

Keywords: exercise; muscle fiber; steroid myopathy.

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Figures

Fig. 1
Fig. 1
Means of muscle fiber diameters in the four groups. In the extensor digitorum longus (EDL) muscle, the steroid groups decreased significantly (p<0.01) compared with the control groups, and the exercise groups increased significantly (p<0.01) compared with the non-exercise groups. In the soleus (SOL) muscle, the steroid groups decreased significantly (p<0.01) compared with the control groups, the exercise groups did not show significant difference from the non-exercise groups. There was the interaction between steroid and exercise statistically. Result from non paired Student's t-test of the group CN did not show significant difference from the group SN.
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