doi: 10.1038/314053a0.
Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens
- PMID: 2579340
- DOI: 10.1038/314053a0
Item in Clipboard
Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens
Nature.
1985 Mar.
Abstract
The hope that hybridoma antibodies would reveal unique cell surface antigens during embryogenesis, differentiation and oncogenesis has been replaced by the realization that such antigens are mainly carbohydrate structures of glycoproteins and glycolipids occurring in many cell types. These findings either may reflect limitations in the methods of selection of hybridoma antibodies or may point to important roles for the diverse carbohydrate structures as receptors for regulators of cell growth and differentiation.
Similar articles
-
Tumor-associated carbohydrate antigens.Annu Rev Immunol. 1984;2:103-26. doi: 10.1146/annurev.iy.02.040184.000535. Annu Rev Immunol. 1984. PMID: 6085749 Review. No abstract available.
-
Glycosphingolipid carriers of carbohydrate antigens of human myeloid cells recognized by monoclonal antibodies.Biochim Biophys Acta. 1985 Jul 30;846(1):26-36. doi: 10.1016/0167-4889(85)90106-5. Biochim Biophys Acta. 1985. PMID: 2410035
-
The antigens Ii, SSEA-1 and ABH are in interrelated system of carbohydrate differentiation antigens expressed on glycosphingolipids and glycoproteins.Adv Exp Med Biol. 1982;152:167-77. Adv Exp Med Biol. 1982. PMID: 6127917
-
Tumour-associated and differentiation antigens on the carbohydrate moieties of mucin-type glycoproteins.Biochem Soc Trans. 1984 Aug;12(4):591-6. doi: 10.1042/bst0120591. Biochem Soc Trans. 1984. PMID: 6208062 Review.
-
Detection of monoclonal antibodies specific for carbohydrate epitopes using periodate oxidation.J Immunol Methods. 1985 Apr 8;78(1):143-53. doi: 10.1016/0022-1759(85)90337-0. J Immunol Methods. 1985. PMID: 2580026
Cited by
-
Heterogeneity of the blood group ABH antigens and variation in the expression of these antigens of secretory granules in human cervical glands. An electron microscopic observation using lectins and monoclonal antibodies.Histochemistry. 1990;94(5):489-96. doi: 10.1007/BF00272612. Histochemistry. 1990. PMID: 2283312
-
Neoglycolipids as probes of oligosaccharide recognition by recombinant and natural mannose-binding proteins of the rat and man.Biochem J. 1989 Aug 15;262(1):131-8. doi: 10.1042/bj2620131. Biochem J. 1989. PMID: 2818558 Free PMC article.
-
Monoclonal antibody FW6 generated against a mucin-carbohydrate of human amniotic fluid recognises a colonic tumour-associated epitope.Br J Cancer. 1992 Apr;65(4):559-65. doi: 10.1038/bjc.1992.114. Br J Cancer. 1992. PMID: 1373294 Free PMC article.
-
A carbohydrate epitope expressed uniquely on the cell surface of Drosophila neurons is altered in the mutant nac (neurally altered carbohydrate).EMBO J. 1988 Nov;7(11):3471-7. doi: 10.1002/j.1460-2075.1988.tb03222.x. EMBO J. 1988. PMID: 2463162 Free PMC article.
-
Degradation of articular cartilage keratan sulphates using hydrazinolysis and nitrous acid. Environment of fucose residues.Biochem J. 1992 Aug 15;286 ( Pt 1)(Pt 1):235-41. doi: 10.1042/bj2860235. Biochem J. 1992. PMID: 1520275 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
