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Meta-Analysis
. 2015 Mar 20;10(3):e0117344.
doi: 10.1371/journal.pone.0117344. eCollection 2015.

Quantifying the evidence for the risk of metabolic syndrome and its components following androgen deprivation therapy for prostate cancer: a meta-analysis

Cecilia Bosco  1 , Danielle Crawley  2 , Jan Adolfsson  3 , Sarah Rudman  4 , Mieke Van Hemelrijck  1
Affiliations
Meta-Analysis

Quantifying the evidence for the risk of metabolic syndrome and its components following androgen deprivation therapy for prostate cancer: a meta-analysis

Cecilia Bosco et al. PLoS One. .

Abstract

Background: No meta-analysis is yet available for the risk of metabolic syndrome (MetS) following androgen deprivation therapy (ADT) for men with prostate cancer. To summarize the evidence for the link between ADT and MetS or its components quantitatively with a meta-analysis including all studies published to date.

Methods: PubMed and Embase were searched using predefined inclusion criteria to perform meta-analyses on the association between metabolic syndrome, hyperglycemia, diabetes, hypertension, dyslipidemia or obesity and androgen deprivation therapy in patients with prostate cancer. Random effects methods were used to estimate pooled relative risks (RRs) and 95% confidence intervals (CI).

Results: A total of nine studies was included. There was a positive association between ADT and risk of MetS (RR: 1.75 (95% CI: 1.27-2.41)). Diabetes was the only MetS component present in more than 3 studies, and also showed an increased risk following ADT (RR: 1.36 (95% CI: 1.17-1.58)).

Conclusion: This is the first quantitative summary addressing the potential risk of MetS following ADT in men with PCa. The positive RRs indicate that there is a need to further elucidate how type and duration of ADT affect these increased risks of MetS and diabetes as the number of men with PCa treated with ADT is increasing.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow chart of study selection for meta-analysis on ADT and MetS.
Fig 2
Fig 2. Forest plot for association between ADT and MetS.
Fig 3
Fig 3. Forest plot for association between ADT and diabetes.
Fig 4
Fig 4. Begg’s funnel plots to test for publication bias for the associations between ADT and diabetes (a) and ADT and diabetes (b).
See this image and copyright information in PMC

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