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Review
. 2015 Sep;213(3):268-77.
doi: 10.1016/j.ajog.2015.03.026. Epub 2015 Mar 17.

The role of shed placental DNA in the systemic inflammatory syndrome of preeclampsia

James D R Hartley  1 , Brian J Ferguson  1 , Ashley Moffett  2
Affiliations
Review

The role of shed placental DNA in the systemic inflammatory syndrome of preeclampsia

James D R Hartley et al. Am J Obstet Gynecol. 2015 Sep.

Abstract

Preeclampsia is a syndrome occurring only in pregnancy characterized by systemic maternal inflammation and associated with the presence of the placenta. How these 2 aspects of the disease are linked has been the subject of numerous theories and ideas. Recently, there has been increasing interest in DNA shed from the placenta into the maternal circulation as a potential agent initiating the inflammatory response. This review will discuss the current evidence and future directions for placental DNA as the linking factor in preeclampsia in the context of other hypotheses.

Keywords: inflammation; placental DNA; preeclampsia.

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  • Reply.
    Moffett A, Hartley JDR, Ferguson BJ. Moffett A, et al. Am J Obstet Gynecol. 2016 Apr;214(4):548-549. doi: 10.1016/j.ajog.2015.12.004. Epub 2015 Dec 12. Am J Obstet Gynecol. 2016. PMID: 26692179 No abstract available.
  • Cell-free fetal DNA in the pathogenesis of preeclampsia.
    McMaster-Fay RA, Hyett JA. McMaster-Fay RA, et al. Am J Obstet Gynecol. 2016 Apr;214(4):548. doi: 10.1016/j.ajog.2015.12.005. Epub 2015 Dec 12. Am J Obstet Gynecol. 2016. PMID: 26692182 No abstract available.

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