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. 2015 Apr 21;33(17):2004-8.
doi: 10.1016/j.vaccine.2015.03.019. Epub 2015 Mar 18.

C-reactive protein response to influenza vaccination as a model of mild inflammatory stimulation in the Philippines

Thomas W McDade  1 , Judith B Borja  2 , Christopher W Kuzawa  3 , Tita Lorna L Perez  2 , Linda S Adair  4
Affiliations

C-reactive protein response to influenza vaccination as a model of mild inflammatory stimulation in the Philippines

Thomas W McDade et al. Vaccine. .

Abstract

Background: C-reactive protein (CRP) is increasingly measured as a marker of systemic inflammation that predicts elevated risk for cardiovascular disease. Influenza vaccination is a mild pro-inflammatory stimulus, and the CRP response to vaccination may provide additional information on individual differences in inflammatory response and risk for disease.

Aim: To document the pattern of CRP response to influenza vaccination among a large sample of older women in the Philippines. The Philippines exemplifies current global trends toward increasing rates of overweight/obesity, but also maintains relatively high rates of infectious disease. The secondary aim of the study is to investigate the impact of infectious symptoms on the pattern of response to vaccination.

Methods: A community-based sample of 934 women (mean age=55.4 years) received the influenza vaccine. CRP was assessed at baseline and 72h post-vaccination. Descriptive, non-parametric, and parametric analyses were implemented to assess the magnitude of CRP response, and to investigate whether responses were associated with baseline CRP or the presence of infectious symptoms prior to vaccination.

Results: Influenza vaccination resulted in a statistically significant CRP response of 0.35mg/L (p<0.001), representing a 30.2% increase from baseline. For individuals with symptoms of infectious disease at baseline, the CRP response was smaller (12.9%) and not statistically significant (p=0.77). Lower CRP at baseline was associated with larger CRP response to vaccination in the entire sample, and among participants without recent symptoms of infection.

Conclusions: Influenza vaccination produces a mild CRP response in the Philippines. This study extends prior research in US and European populations validating influenza vaccination as an in vivo model for investigating the dynamics of inflammation, but also raises potential complications in settings where rates of infectious disease are elevated.

Keywords: C-reactive protein; Inflammation; Influenza vaccination.

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Figures

Figure 1
Figure 1
CRP response to influenza vaccination. Median concentrations of CRP at baseline and three days following vaccination (error bars represent 25th and 75th percentile values).
Figure 2
Figure 2
Scatterplot of CRP response to vaccination in relation to baseline CRP concentration.
See this image and copyright information in PMC

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