Observational Study

. 2015 Mar 20;5(3):e006897.

doi: 10.1136/bmjopen-2014-006897.

Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: protocol for DIET-HD, a prospective multinational cohort study

Suetonia C Palmer¹, Marinella Ruospo², Katrina L Campbell³, Vanessa Garcia Larsen⁴, Valeria Saglimbene⁵, Patrizia Natale⁵, Letizia Gargano⁵, Jonathan C Craig⁶, David W Johnson⁷, Marcello Tonelli⁸, John Knight⁹, Anna Bednarek-Skublewska¹⁰, Eduardo Celia⁵, Domingo Del Castillo⁵, Jan Dulawa¹¹, Tevfik Ecder⁵, Elisabeth Fabricius⁵, João Miguel Frazão¹², Ruben Gelfman⁵, Susanne Hildegard Hoischen⁵, Staffan Schön⁵, Paul Stroumza⁵, Delia Timofte⁵, Marietta Török⁵, Jörgen Hegbrant⁵, Charlotta Wollheim⁵, Luc Frantzen⁵, G F M Strippoli¹³; DIET-HD Study investigators

Collaborators, Affiliations

Collaborators

DIET-HD Study investigators:
S Raña, M Serrano, S Claros, M Arias, L Petracci, M Arana, P De Rosa, A Gutierrez, M Simon, V Vergara, M Tosi, M Cernadas, I Vilamajó, D Gravac, M Paulón, L Penayo, G Carrizo, M Ghiani, G Perez, O Da Cruz, D Galarce, M Gravielle, E Vescovo, R Paparone, C Mato Mira, E Mojico, O Hermida, D Florio, M Yucoswky, W Labonia, D Rubio, G Di Napoli, A Fernandez, H Altman, J Rodriguez, S Serrano, G Valle, M Lobos, V Acosta, G Corpacci, M Jofre, L Gianoni, G Chiesura, M Capdevila, J Montenegro, J Bequi, J Dayer, A Gómez, C Calderón, E Abrego, C Cechín, J García, J Corral, M Natiello, A Coronel, M Muñiz, V Muñiz, A Bonelli, F Sanchez, S Maestre, S Olivera, M Camargo, V Avalos, E Geandet, M Canteli, A Escobar, E Sena, S Tirado, A Peñalba, G Neme, M Cisneros, R Oliszewski, V Nascar, M Daud, S Mansilla, A Paredes Álvarez, L Gamín, M Arijón, M Coombes, M Zapata, C Boriceanu, M Lankester, J L Poignet, Y Saingra, M Indreies, J Santini, M Amar, A Robert, P Bouvier, T Merzouk, F Villemain, A Pajot, F Tollis, M Brahim-Bounab, A Benmoussa, S Albitar, M C Guimont, P Ciobotaru, A Guerin, M Diaconita, SHH, J Saupe, I Ullmann, S Grosser, J Kunow, S Grueger, D Bischoff, J Benders, P Worch, T Pfab, N Kamin, M Roesch, K Albert, I Csaszar, E Kiss, D Kosa, A Orosz, J Redl, L Kovacs, E Varga, M Szabo, K Magyar, E Zajko, A Bereczki, J Csikos, E Kerekes, A Mike, K Steiner, E Nemeth, K Tolnai, A Toth, J Vinczene, Sz Szummer, E Tanyi, M Szilvia, A M Murgo, N Sanfilippo, N Dambrosio, C Saturno, G Matera, M Benevento, V Greco, G di Leo, S Papagni, F Alicino, A Marangelli, F Pedone, A V Cagnazzo, R Antinoro, M L Sambati, C Donatelli, F Ranieri, F Torsello, P Steri, C Riccardi, A Flammini, L Moscardelli, E Boccia, M Mantuano, R Di Toro Mammarella, M Meconizzi, R Fichera, A D'Angelo, G Latassa, A Molino, M Fici, A Lupo, G Montalto, S Messina, C Capostagno, G Randazzo, S Pagano, G Marino, D Rallo, A Maniscalco, O M Trovato, C Strano, A Failla, A Bua, S Campo, P Nasisi, A Salerno, S Laudani, F Grippaldi, D Bertino, D V Di Benedetto, A Puglisi, S Chiarenza, M Lentini Deuscit, C M Incardona, G Scuto, C Todaro, A Dino, D Novello, A Coco, E Bocheńska-Nowacka, A Jaroszyński, J Drabik, M Wypych-Birecka, D Daniewska, M Drobisz, K Doskocz, G Wyrwicz-Zielińska, A Kosicki, W S Ślizień, P Rutkowski, S Arentowicz, S Dzimira, M Grabowska, J Ostrowski, A Całka, T Grzegorczyk, W Dżugan, M Mazur, M Myślicki, M Piechowska, D Kozicka, A R Mira, V Martins, B Velez, T Pinheiro, E Agapi, C L Ardelean, A Baidog, G Bako, M Barb, A Blaga, E Bodurian, V Bumbea, E Dragan, D Dumitrache, L Florescu, N Havasi, S Hint, R Ilies, A G M Mandita, R I Marian, S L Medrihan, L Mitea, S Mitea, R Mocanu, D C Moro, M Nitu, M L Popa, M Popa, E Railean, A R Scuturdean, K Szentendrey, C L Teodoru, A Varga, A Bernat, B De la Torre, A Lopez, J Martin, G Cuesta, R M Rodriguez, F Ros, M Garcia, E Orero, E Ros, E Fabricius, J Goch, K S Katzarski, A Wulcan, H Akbiber, H Arslan, L Bicen, A Buyukkiraz, R Celik, I S Dogan, S Erkalkan, A Ertas, U Hark, E Iravul, M Karakaya, K Mengu, S Ongun, Z Ozkan, A Ozlu, N Ozveren, H M Sifil, N Sonmez Turksoz, Z Yilmaz

Affiliations

¹ Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand.
² Diaverum Medical Scientific Office, Lund, Sweden Division of Nephrology and Transplantation, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.
³ Department of Nutrition and Dietetics, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
⁴ Faculty of Medicine, National Health and Lung Institute, Imperial College of Science, Technology, and Medicine, Royal Brompton campus, London, UK.
⁵ Diaverum Medical Scientific Office, Lund, Sweden.
⁶ Sydney School of Public Health, Edward Ford Building, University of Sydney, Sydney, New South Wales, Australia.
⁷ Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
⁸ Cumming School of Medicine, University of Calgary, 2500 University Drive Northwest, Calgary, Alberta, Canada.
⁹ The George Institute for Global Health, Sydney, New South Wales, Australia.
¹⁰ Diaverum Medical Scientific Office, Lund, Sweden Department of Nephrology, Medical University of Lublin, Lublin, Poland.
¹¹ Diaverum Medical Scientific Office, Lund, Sweden Department of Internal Medicine, Metabolic Diseases, Medical University of Silesia, Katowice, Poland.
¹² Diaverum Medical Scientific Office, Lund, Sweden Nephrology and Infectiology Research and Development Group, INEB, and School of Medicine, Porto University, Porto, Portugal.
¹³ Diaverum Medical Scientific Office, Lund, Sweden Sydney School of Public Health, Edward Ford Building, University of Sydney, Sydney, New South Wales, Australia Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy Diaverum Academy, Bari, Italy.

PMID: 25795691
PMCID: PMC4368922
DOI: 10.1136/bmjopen-2014-006897

Observational Study

Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: protocol for DIET-HD, a prospective multinational cohort study

Suetonia C Palmer et al. BMJ Open. 2015.

. 2015 Mar 20;5(3):e006897.

doi: 10.1136/bmjopen-2014-006897.

Authors

Collaborators

DIET-HD Study investigators:
S Raña, M Serrano, S Claros, M Arias, L Petracci, M Arana, P De Rosa, A Gutierrez, M Simon, V Vergara, M Tosi, M Cernadas, I Vilamajó, D Gravac, M Paulón, L Penayo, G Carrizo, M Ghiani, G Perez, O Da Cruz, D Galarce, M Gravielle, E Vescovo, R Paparone, C Mato Mira, E Mojico, O Hermida, D Florio, M Yucoswky, W Labonia, D Rubio, G Di Napoli, A Fernandez, H Altman, J Rodriguez, S Serrano, G Valle, M Lobos, V Acosta, G Corpacci, M Jofre, L Gianoni, G Chiesura, M Capdevila, J Montenegro, J Bequi, J Dayer, A Gómez, C Calderón, E Abrego, C Cechín, J García, J Corral, M Natiello, A Coronel, M Muñiz, V Muñiz, A Bonelli, F Sanchez, S Maestre, S Olivera, M Camargo, V Avalos, E Geandet, M Canteli, A Escobar, E Sena, S Tirado, A Peñalba, G Neme, M Cisneros, R Oliszewski, V Nascar, M Daud, S Mansilla, A Paredes Álvarez, L Gamín, M Arijón, M Coombes, M Zapata, C Boriceanu, M Lankester, J L Poignet, Y Saingra, M Indreies, J Santini, M Amar, A Robert, P Bouvier, T Merzouk, F Villemain, A Pajot, F Tollis, M Brahim-Bounab, A Benmoussa, S Albitar, M C Guimont, P Ciobotaru, A Guerin, M Diaconita, SHH, J Saupe, I Ullmann, S Grosser, J Kunow, S Grueger, D Bischoff, J Benders, P Worch, T Pfab, N Kamin, M Roesch, K Albert, I Csaszar, E Kiss, D Kosa, A Orosz, J Redl, L Kovacs, E Varga, M Szabo, K Magyar, E Zajko, A Bereczki, J Csikos, E Kerekes, A Mike, K Steiner, E Nemeth, K Tolnai, A Toth, J Vinczene, Sz Szummer, E Tanyi, M Szilvia, A M Murgo, N Sanfilippo, N Dambrosio, C Saturno, G Matera, M Benevento, V Greco, G di Leo, S Papagni, F Alicino, A Marangelli, F Pedone, A V Cagnazzo, R Antinoro, M L Sambati, C Donatelli, F Ranieri, F Torsello, P Steri, C Riccardi, A Flammini, L Moscardelli, E Boccia, M Mantuano, R Di Toro Mammarella, M Meconizzi, R Fichera, A D'Angelo, G Latassa, A Molino, M Fici, A Lupo, G Montalto, S Messina, C Capostagno, G Randazzo, S Pagano, G Marino, D Rallo, A Maniscalco, O M Trovato, C Strano, A Failla, A Bua, S Campo, P Nasisi, A Salerno, S Laudani, F Grippaldi, D Bertino, D V Di Benedetto, A Puglisi, S Chiarenza, M Lentini Deuscit, C M Incardona, G Scuto, C Todaro, A Dino, D Novello, A Coco, E Bocheńska-Nowacka, A Jaroszyński, J Drabik, M Wypych-Birecka, D Daniewska, M Drobisz, K Doskocz, G Wyrwicz-Zielińska, A Kosicki, W S Ślizień, P Rutkowski, S Arentowicz, S Dzimira, M Grabowska, J Ostrowski, A Całka, T Grzegorczyk, W Dżugan, M Mazur, M Myślicki, M Piechowska, D Kozicka, A R Mira, V Martins, B Velez, T Pinheiro, E Agapi, C L Ardelean, A Baidog, G Bako, M Barb, A Blaga, E Bodurian, V Bumbea, E Dragan, D Dumitrache, L Florescu, N Havasi, S Hint, R Ilies, A G M Mandita, R I Marian, S L Medrihan, L Mitea, S Mitea, R Mocanu, D C Moro, M Nitu, M L Popa, M Popa, E Railean, A R Scuturdean, K Szentendrey, C L Teodoru, A Varga, A Bernat, B De la Torre, A Lopez, J Martin, G Cuesta, R M Rodriguez, F Ros, M Garcia, E Orero, E Ros, E Fabricius, J Goch, K S Katzarski, A Wulcan, H Akbiber, H Arslan, L Bicen, A Buyukkiraz, R Celik, I S Dogan, S Erkalkan, A Ertas, U Hark, E Iravul, M Karakaya, K Mengu, S Ongun, Z Ozkan, A Ozlu, N Ozveren, H M Sifil, N Sonmez Turksoz, Z Yilmaz

Affiliations

¹ Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand.
² Diaverum Medical Scientific Office, Lund, Sweden Division of Nephrology and Transplantation, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.
³ Department of Nutrition and Dietetics, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
⁴ Faculty of Medicine, National Health and Lung Institute, Imperial College of Science, Technology, and Medicine, Royal Brompton campus, London, UK.
⁵ Diaverum Medical Scientific Office, Lund, Sweden.
⁶ Sydney School of Public Health, Edward Ford Building, University of Sydney, Sydney, New South Wales, Australia.
⁷ Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
⁸ Cumming School of Medicine, University of Calgary, 2500 University Drive Northwest, Calgary, Alberta, Canada.
⁹ The George Institute for Global Health, Sydney, New South Wales, Australia.
¹⁰ Diaverum Medical Scientific Office, Lund, Sweden Department of Nephrology, Medical University of Lublin, Lublin, Poland.
¹¹ Diaverum Medical Scientific Office, Lund, Sweden Department of Internal Medicine, Metabolic Diseases, Medical University of Silesia, Katowice, Poland.
¹² Diaverum Medical Scientific Office, Lund, Sweden Nephrology and Infectiology Research and Development Group, INEB, and School of Medicine, Porto University, Porto, Portugal.
¹³ Diaverum Medical Scientific Office, Lund, Sweden Sydney School of Public Health, Edward Ford Building, University of Sydney, Sydney, New South Wales, Australia Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy Diaverum Academy, Bari, Italy.

PMID: 25795691
PMCID: PMC4368922
DOI: 10.1136/bmjopen-2014-006897

Abstract

Introduction: Adults with end-stage kidney disease (ESKD) treated with haemodialysis experience mortality of between 15% and 20% each year. Effective interventions that improve health outcomes for long-term dialysis patients remain unproven. Novel and testable determinants of health in dialysis are needed. Nutrition and dietary patterns are potential factors influencing health in other health settings that warrant exploration in multinational studies in men and women treated with dialysis. We report the protocol of the "DIETary intake, death and hospitalisation in adults with end-stage kidney disease treated with HaemoDialysis (DIET-HD) study," a multinational prospective cohort study. DIET-HD will describe associations of nutrition and dietary patterns with major health outcomes for adults treated with dialysis in several countries.

Methods and analysis: DIET-HD will recruit approximately 10,000 adults who have ESKD treated by clinics administered by a single dialysis provider in Argentina, France, Germany, Hungary, Italy, Poland, Portugal, Romania, Spain, Sweden and Turkey. Recruitment will take place between March 2014 and June 2015. The study has currently recruited 8000 participants who have completed baseline data. Nutritional intake and dietary patterns will be measured using the Global Allergy and Asthma European Network (GA(2)LEN) food frequency questionnaire. The primary dietary exposures will be n-3 and n-6 polyunsaturated fatty acid consumption. The primary outcome will be cardiovascular mortality and secondary outcomes will be all-cause mortality, infection-related mortality and hospitalisation.

Ethics and dissemination: The study is approved by the relevant Ethics Committees in participating countries. All participants will provide written informed consent and be free to withdraw their data at any time. The findings of the study will be disseminated through peer-reviewed journals, conference presentations and to participants via regular newsletters. We expect that the DIET-HD study will inform large pragmatic trials of nutrition or dietary interventions in the setting of advanced kidney disease.

Keywords: EPIDEMIOLOGY; NUTRITION & DIETETICS.

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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References

1. U.S. Renal Data System, USRDS 2009 Annual Data Report: Atlas of End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2009.
1. Palmer S, Hanson C, Craig J et al. . Dietary and fluid restriction in CKD: a thematic synthesis of patient views from qualitative studies. Am J Kidney Dis 2014. doi:10.1053/j.ajkd.2014.09.012 [Epub ahead of print 6 Nov 2014]. - PubMed
1. Kovesdy CP, Shinaberger CS, Kalantar-Zadeh K. Epidemiology of dietary nutrient intake in ESRD. Semin Dial 2010;23:353–8. 10.1111/j.1525-139X.2010.00745.x - DOI - PMC - PubMed
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Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: protocol for DIET-HD, a prospective multinational cohort study

Collaborators

Affiliations

Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: protocol for DIET-HD, a prospective multinational cohort study

Authors

Collaborators

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical