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. 1985 Jan;40(1):70-2.
doi: 10.1111/j.1398-9995.1985.tb04157.x.

Bronchial and basophil reaction to polymyxin B in asthmatic patients

P Górski, J Rozniecki, B Kuźmińska, J Grzegorczyk

Bronchial and basophil reaction to polymyxin B in asthmatic patients

P Górski et al. Allergy. 1985 Jan.

Abstract

The hypothesis that increased reactivity to polymyxin B in asthmatic patients is not limited to the bronchi but also exists in basophils was investigated in 26 atopic asthmatic subjects. Quantification of basophil degranulation induced by polymyxin B was performed using a flow-cytometric method. Significant degranulation was noted in 17 patients, but in none of 10 healthy controls. There was close relationship between basophil "releasability" to polymyxin B and bronchial reactivity to inhaled polymyxin B. These findings support the hypothesis.

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